Children and adolescent patients with pre-existing type 1 diabetes and additional comorbidities have an increased risk of hospitalization from COVID-19; data from the T1D exchange COVID registry

¹T1D Exchange, Quality Improvement and Population Health, Boston, United States, ²Monument Health, Rapid City, United States, ³NYU Langone, New York, United States, ⁴Barbara Davis Center, Colorado, United States, ⁵Children Hospital of Orange County, Orange, United States, ⁶Vanderbilt Children Hospital, Nashville, United States, ⁷University of Mississippi School of Population Health, Jackson, United States

Introduction: Children and adolescents with pre-existing type 1 diabetes (T1D) diagnosed with COVID-19 are at risk of adverse outcomes such as hospitalizations and diabetic ketoacidosis (DKA). There is limited data on the association between the presence of one or more comorbidities and the risk of adverse outcomes for patients with pre-existing T1D and COVID19.

Objectives: This study’s aim is to determine if pediatric and adolescent patients with T1D and other pre-existing comorbidities were more likely to experience adverse outcomes than T1D patients with COVID-19 who did not have any other comorbidities.

Methods: Data from 592 patients with previously established T1D aged <24 years with COVID-19 were analyzed from the T1Dx COVID-19 Surveillance Registry. Data were collected from 52 endocrinology clinics across the US using an online survey tool. Each clinic completed the survey using electronic medical record (EMR) data between April 2020 and May 2021. Descriptive statistics were used to describe the study population, and multivariate logistic regression models were used to analyze the relationship between age, insurance type, use of diabetes technology, presence of comorbidities, adverse outcomes, and hospitalization.

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